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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   3

Issue No. :  3

Year :  2010

Pages :   942-944

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Development of Fast Dispersible Tablets of Carvedilol: Effect of Functionality of Superdisintegrants



Address:   Mahaveer Singh1, Gautam Singhvi1, S.G. Kaskhedikar2, Love soni2
1Pharmacy Group, Birla Institute of Technology and Science, Pilani (Rajasthan)
2Department of pharmacy SGSITS,indore
*Corresponding Author
DOI No: Not Available

ABSTRACT:
Carvedilol is a vasodilating non-selective beta-blocking agent with antioxidant properties. Fast dispersible tablets have been prepared by wet granulation method. Effect of binder and superdisintegrants (such as, croscarmellose sodium, sodium starch glycolate and crospovidone) on disintegration time, drug content, in-vitro release and stability parameters has been studied. Developed formula was compared with marketed formulation. Carvedilol tablet dosage form was developed by considering COREG as innovator. All dissolution profile including stability batches were matched and F1, F2 factor were found to be satisfactory. Evaluation parameters for developed tablet were found within range specified in pharmacopoeia. All the work has done at Torrent Research Centre and SGSITS, Indore with their kind support.
KEYWORDS:
Formulation Development of a Stable Fast Dispersible Tablet of Carvedilol that provide rapid drug release and produce improved bioavailability
Cite:
Mahaveer Singh, Gautam Singhvi, SG Kaskhedikar, Love soni. Development of Fast Dispersible Tablets of Carvedilol: Effect of Functionality of Superdisintegrants. Research J. Pharm. and Tech.3 (3): July-Sept. 2010; Page 942-944.
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