Journal :   Research Journal of Pharmacy and Technology

Volume No. :   3

Issue No. :  3

Year :  2010

Pages :   938-941

ISSN Print :  0974-3618

ISSN Online :  0974-360X


Registration

Allready Registrered
Click to Login

Synthesis, Spectral Studies and Biological Activity of Some 1, 5-Benzodiazepine Derivatives



Address:   Chandak B.G.1*, Sarpate R.V.1 , Chatterjee N.R.2 and Baheti K.G.2
1Siddhant College of Pharmacy, Sudumbare, Pune. 2Department of Pharmaceutical Chemistry, Pad Dr. D.Y. P. College of Pharmacy, Akurdi, Pune-411044
*Corresponding Author
DOI No: Not Available

ABSTRACT:
An efficient method for green synthesis of some 2, 3-dihydro 1H-1, 5-benzodiazepine derivatives has been developed by simple cyclocondensation reaction of o-phenylendiamine with aromatic, cyclic and acyclic ketones as well as 1, 3-ß dicarbonyl compounds in presence of catalytic amount of silica gel under ultrasound irradiation. The title compounds have been characterized by physico-chemical methods and screened for anti-microbial activity in order to evaluate for the effectivity against Crofloxin and Ciclopiroxoamine as standard.
KEYWORDS:
1, 5-benzodiazepines, o-phenylenediamine, ketones, 1, 3-β dicarbonyl compounds, silica gel, ultrasound irradiation, anti-microbial.
Cite:
Chandak BG, Sarpate RV, Chatterjee NR, Baheti KG. Synthesis, Spectral Studies and Biological Activity of Some 1, 5-Benzodiazepine Derivatives. Research J. Pharm. and Tech.3 (3): July-Sept. 2010; Page 938-941.
[View HTML]      [View PDF]



Visitor's No. :   366130