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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   3

Issue No. :  3

Year :  2010

Pages :   

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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In-Vitro Dissolution Testing of Ibuprofen Using Compendial and Biorelevant Dissolution Media



Address:   1NCRD’s Sterling Institute of Pharmacy, Nerul, Navi Mumbai-400706. 2Chitkara School of Pharmacy, Chitkara University, Solan-174103 (HP) 3Rajendra Institute of Technology and Sciences, Sirsa-125055 (Haryana) 4Lachoo Memorial College of Science and Techn
DOI No: Not Available

ABSTRACT:
In present study, the performance of biorelevant and compendial dissolution media was compared to test dissolution of drugs belonging to class II according to Biopharmaceutic Classification Scheme (BCS). The solubility of Ibuprofen, a weakly acidic drug, was determined in various media (water, Phosphate buffer pH 7.2, FaSSIF and FeSSIF) having different pH to calculate D/S values in different media. Invitro dissolution of marketed tablets was studied in compendial media (water, phosphate buffer pH 7.2) and biorelevant media (FaSSIF and FeSSIF). Dissolution of Ibuprofen was found to be dependent upon pH. In all cases, the mean dissolution profiles in biorelevant media were in concordance with in vivo findings published earlier. The method was validated in terms of linearity and precision. The similarity factor in different media was also evaluated.
KEYWORDS:
Biorelevant Dissolution Media, Biopharmaceutics Classification System, Dissolution Test, FaSSIF, FeSSIF.
Cite:
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