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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   3

Issue No. :  3

Year :  2010

Pages :   

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Formulation and Evaluation of Tramadol Hydrochloride Microspheres for Oral Delivery

Address:   1Division of Pharmaceutics, Dept. of Pharmaceutical Technology, Jadavpur University, Kolkata - 700 032, India. 2Dept. of Pharmaceutics, Bharathi College of Pharmacy, Bharathi Nagara, Mandya Dist, Karnataka -571 422, India. 3Dept. of Pharmacology, Bharat
DOI No: Not Available

Microspheres (MS) of Tramadol Hydrochloride (TM) were prepared by coacervation method without the use of chemical cross–linking agent (glutaraldehyde) to avoid the toxic reactions and other undesirable effects of the chemical cross-linking agent. Alternatively, ionotropic gelation was employed by using sodium-tripolyphosphate (Na-TPP) as cross linking agent. Chitosan was used as polymer. All the prepared microspheres were subjected to various physico-chemical studies, such as drug-polymer compatibility by thin layer chromatography (TLC) and Fourier Transform Infrared Spectroscopy (FTIR), surface morphology by scanning electron microscopy (SEM), frequency distribution, encapsulation efficiency by High Performance Thin Layer Chromatography (HPTLC), in-vitro drug release characteristics and release kinetics. TLC and FTIR studies indicated no drug-polymer incompatibility. Surface smoothness of MS was increased by increasing the polymer concentration, which was confirmed by SEM. As the drug to polymer ratio was increased, the mean particle size (MPS) of TM microspheres was also increased. A maximum of 87% of drug entrapment efficiency was obtained by the method employed. All the MS showed initial burst release followed by a Fickian diffusion mechanism. It is possible to design a controlled drug delivery system for the prolonged release of TM, improving therapy by possible reduction of time intervals between administrations.
Tramadol Hydrochloride; Microspheres; Coacervation; Chitosan; In-vitro release kinetics.
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