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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   3

Issue No. :  3

Year :  2010

Pages :   861-864

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Simultaneous Determination of Telmisartan and Ramipril in Tablet Dosage Form by Spectrophotometry



Address:   Krishanu Pal1, M. Bhagavan Raju1, K. Pavan Kumar1, Rahul Chakravorthy2
1Dept. of Pharmaceutical Analysis and Chemistry, CM College of Pharmacy, Maisammaguda, Dhulapally Hakimpet post, Kompally, Secunderabad -500014, Andhra Pradesh India.
2Dept. of Pharmaceutical Analysis and chemistry, Azad College of pharmacy, Moinabad, Shaikpet, Hyderabad
*Corresponding Author
DOI No: Not Available

ABSTRACT:
Two accurate, precise, sensitive and economical procedures for simultaneous estimation of Telmisartan (TEL) and Ramipril (RP) in tablet dosage form were developed. The method employed were simultaneous equation method (I), first order derivative spectroscopic method (II).The first method employs wavelength 218.94 and 295.55 nm. The second method employs wavelength 265.76 and 312.99 nm for TEL and 223.95 nm for RP. The linearity of these drugs at all the selected wavelengths for TEL is 4 -20 µg/ml, 2-10 µg/ml for RP. The concentration of these drugs was evaluated in laboratory mixture and marketed formulation. Accuracy was determined by recovery studies from tablet dosage forms and ranges form 98.67- 99.77 for Telmisartan, 97.08-101.20 for Ramipril. Precision of method was find out as repeatability day to day, and analyst to analyst variation and shows the values within acceptable limits (R.S.D<2 percent).
KEYWORDS:
Telmisartan, Ramipril, Simultaneous and First order derivative method.
Cite:
Krishanu Pal, M Bhagavan Raju, K Pavan Kumar, Rahul Chakravorthy. Simultaneous Determination of Telmisartan and Ramipril in Tablet Dosage Form by Spectrophotometry. Research J. Pharm. and Tech.3 (3): July-Sept. 2010; Page 861-864.
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