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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   3

Issue No. :  3

Year :  2010

Pages :   

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Multi Particulate Extended Release Formulation for Propranolol Hydrochloride



Address:   Department of Pharmaceutics, RKDF College of Pharmacy, Bhopal (India)
DOI No: Not Available

ABSTRACT:
The objectives of the present investigation were optimization and formulation development of Propranolol HCl multi-particulate beads and their comparison with the marketed formulation. Different drug: polymer ratio were taken and optimized for the best possible drug release. Various processes controlling like load, fluidization, total polymer content, atomization pressure, and spray rate were optimized. Extrusion spheronisation was done to prepare core pellets containing drug. Micro Crystalline Cellulose was selected as a spheronizing agent and Hydroxy Propyl Methyl Cellulose used as binder. Binder concentration 2.5% was showing the optimum release and good spherical shape core pellets. Coating was done by ethyl cellulose (EC) N50: HPMC in ratio of 70:30 and Triethyl citrate (10% of EC) as plasticizer. The release profile of optimized formulation and MF was similar and confirmed by calculation of two factors i.e. differential factor (F2; 71.85) and similarity factor (F1; 9.15).
KEYWORDS:
Multi-particulate beads, Propranolol HCl, Extrusion spheronisation, differential factor, similarity factor
Cite:
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