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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   3

Issue No. :  3

Year :  2010

Pages :   818-820

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Design and Evaluation of Nimesulide Lozenges for Pediatrics



Address:   Mohd. Yousuf Ali*1, Md. Shamim Qureshi1, Md. Hamed1, Byasabhusan Das1 and K. Purushotham Rao2
1Dept. of Pharmaceutics, Anwarul Uloom College of Pharmacy, New Mallepally, Hyderabad 500001, India.
2Dept. of Pharmaceutics, HKE Society’s College of Pharmacy, Gulbarga-585105, Karnataka, India
*Corresponding Author
DOI No: Not Available

ABSTRACT:
Most of the illnesses are associated with fevers, headache and body aches and it is very difficult for parents to manage pediatric patients to administer the drug dosage forms. In the present investigation, an attempt has been made to formulate medicated sugar based tablet lozenges for kids using Nimesulide as model drug, which is commonly used analgesic and anti-pyretic. There are many dosage forms available in the market but still there is a need for new dosage form which acts effectively. So the present investigation has been taken up to design, prepare and evaluate hard candy based medicated tablet lozenges to meet the need of improved action dosage form. All the formulations prepared were subjected to various physico- chemical parameters such as hardness, drug content uniformity, weight variation, moisture content etc. The prepared formulations have a hardness of 9-12 Kg/cm2, not gritty, mouth feel freshness taste. Stability studies of selected formulations were also carried out at 37oC and 45oC for a period of six months. Formulations were tested for drug excipient interactions subjecting to IR Spectral analysis. In-vitro drug dissolution studies showed 97.62% for F0 formulation in 15 Minutes and 85.04% for F1 formulation release of drug in 30 minutes. The hard boiled candy lozenges can provide an attractive alternative formulation in the treatment of pain and fever in pediatrics.
KEYWORDS:
Nimesulide, lozenges, pediatrics, fever, headache.
Cite:
Mohd Yousuf Ali, Md Shamim Qureshi, Md Hamed, Byasabhusan Das and K Purushotham Rao. Design and Evaluation of Nimesulide Lozenges for Pediatrics. Research J. Pharm. and Tech.3 (3): July-Sept. 2010; Page 818-820.
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