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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   3

Issue No. :  3

Year :  2010

Pages :   

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Antiulcer Activity of Methanolic Extract of Cassia angustifolia Bark and Its Comparison with Ranitidine in Shay Rat.



Address:   1Sri Satya Sai college of Pharmacy, Sehore, M.P. 2Dept. of Pharmacy, Utkal University Bhubaneswar, 754004 3College of Pharmaceutical Sciences, Mohuda, Berhampur, Orissa.
DOI No: Not Available

ABSTRACT:
Methanolic extract of Cassia angustifolia bark was tested for its anti gastric ulcer and compared with anti ulcer of ranitidine in shay rat model. Oral dose with 5mg/kg body weight of ranitidine showed complete absence of ulceration in shay rats. The anti gastric ulcer activity of Cassia angustifolia Methanolic extract (800mg/kg) body weight was found equal to the effect produced by 5mg/kg Ranitidine in this model. Oral administration of methanol extract (800 Mg. /Kg) Cassia angustifolia bark showed complete inhibition of ulceration and significant reduction in free acidity, Total acidity peptic activity and volume of gastric juice secreted were found.
KEYWORDS:
Cassia angustifolia, total acidity, free acidity, peptic activity and ulcer index.
Cite:
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