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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   3

Issue No. :  3

Year :  2010

Pages :   798-800

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Validated UV Spectrophotometric Method for Estimation of Sitagliptin Phosphate in Tablet Dosage Form.



Address:   Sachin Patil1*, B. Ramesh1, A.R. Hareesh2 and Kiran Patil3
1Sri Adichunchanagiri College of Pharmacy, B. G. Nagara-571448, Tal: Nagamangala Dist: (Mandya), Karnataka, India

2Government College of Pharmacy, Vidyanagar, Karad, Dist-Satara, Maharashtra-415 124, India.
*Corresponding Author
DOI No: Not Available

ABSTRACT:
Sitagliptin phosphate is a new class of oral antihyperglycemic agents and it is potent and selective inhibitor of dipeptidyl peptidase-IV (DPP-IV) for the treatment of Type 2 diabetes. No method is available for routine analysis of sitagliptine phosphate. Here we have developed simple, accurate and rapid UV spectrophotometric method for estimation of Sitagliptin phosphate from tablet formulation. The drug obeyed the Beer’s law and showed good correlation. It showed absorption maxima at 272.5 nm in methanol. The linearity was observed between 35 – 85 mcg/ml. The results of analysis were validated by recovery studies. The recovery was more than 99%. The method was found to be simple, rapid, accurate, precise and reproducible.
KEYWORDS:
Sitagliptin phosphate, UV–Vis Spectrophotometry, Recovery.
Cite:
Sachin Patil, B Ramesh, AR Hareesh, Kiran Patil. Validated UV Spectrophotometric Method for Estimation of Sitagliptin Phosphate in Tablet Dosage Form. Research J. Pharm. and Tech.3 (3): July-Sept. 2010; Page 798-800.
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