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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   3

Issue No. :  3

Year :  2010

Pages :   

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Validated UV Spectrophotometric Method for Estimation of Sitagliptin Phosphate in Tablet Dosage Form.

Address:   1Sri Adichunchanagiri College of Pharmacy, B. G. Nagara-571448, Tal: Nagamangala Dist: (Mandya), Karnataka, India
2Government College of Pharmacy, Vidyanagar, Karad, Dist-Satara, Maharashtra-415 124, India.
DOI No: Not Available

Sitagliptin phosphate is a new class of oral antihyperglycemic agents and it is potent and selective inhibitor of dipeptidyl peptidase-IV (DPP-IV) for the treatment of Type 2 diabetes. No method is available for routine analysis of sitagliptine phosphate. Here we have developed simple, accurate and rapid UV spectrophotometric method for estimation of Sitagliptin phosphate from tablet formulation. The drug obeyed the Beer’s law and showed good correlation. It showed absorption maxima at 272.5 nm in methanol. The linearity was observed between 35 – 85 mcg/ml. The results of analysis were validated by recovery studies. The recovery was more than 99%. The method was found to be simple, rapid, accurate, precise and reproducible
Sitagliptin phosphate, UV–Vis Spectrophotometry, Recovery
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