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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   3

Issue No. :  3

Year :  2010

Pages :   758-761

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Identification and Characterization of Photoproduct Obtained By Photodegradation of Aceclofenac



Address:   Nilesh Patel1,*, Shailesh Shah2, Ishwarsinh Rathod3, Dhaval Patel4 and Biraju Patel4
1Department of Pharmaceutical Sciences, Saurashtra University, Rajkot-360005, Gujarat, India.
2Department of Quality Assurance, Maliba pharmacy College, Bardoli, Gujarat, India.
3Department of Quality Assurance, L.M. College of Pharmacy, Ahmedabad-380009, Gujarat, India.
4Veerayatan Institute of Pharmacy, Mandvi-370460, Gujarat, India
*Corresponding Author
DOI No: Not Available

ABSTRACT:
Aceclofenac is [[[2-[(2, 6-dichlorophenyl) amino] phenyl] acetyl] oxy] acetic acid. Photodegradation product of aceclofenac in methanol was synthesized in laboratory. Photodegradation product characterized and identified by Mass spectrum, Infrared spectrum and HPTLC study. Photodegradation of Aceclofenac in methanol gives Methyl- [[[2-[(2,6-dichlorophenyl) amino] phenyl] acetyl] oxy] acetate (Methyl ester of Aceclofenac) which is also reported in British pharmacopoeia as one of the impurities.
KEYWORDS:
Aceclofenac, Photodegradation, Photoproduct.
Cite:
Nilesh Patel, Shailesh Shah, Ishwarsinh Rathod, Dhaval Patel, Biraju Patel. Identification and Characterization of Photoproduct Obtained By Photodegradation of Aceclofenac. Research J. Pharm. and Tech.3 (3): July-Sept. 2010; Page 758-761.
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