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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   3

Issue No. :  3

Year :  2010

Pages :   

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Development and In Vitro Evaluation of Extended Release Matrix Tablet of Metoprolol Succinate



Address:   1Sharad Pawar College of Pharmacy, Wanadongri, Hingna Road, Nagpur- 441110 2Vidyabharti College of Pharmacy, C.K. Naidu Road, Camp, Amravati
DOI No: Not Available

ABSTRACT:
The objective of the present study was to develop extended release matrix tablets of metoprolol succinate (25mg and 50mg label claim), to increase bioavailability; deliver the drug at a near constant rate for approximately 20 hrs independent of food intake and gastrointestinal pH. The dry granulation technique was used to compress the tablet and HPMC –K-100, Hydroxy propyl cellulose, Ethyl cellulose were used as matrixing agent. The tablets were evaluated for thickness, hardness, weight variation, friability, in vitro swelling characteristics of the matrix polymer and dissolution studies; also the drug release from the prepared tablet was compared with the marketed tablet.
KEYWORDS:
Metoprolol succinate, extended release, HPMC, EC, HPC
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