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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   3

Issue No. :  3

Year :  2010

Pages :   740-743

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Anti-inflammatory, Analgesic and Antimicrobial Activity of Some Novel Schiff’s bases of N-aryl anthranilic acid Derivatives



Address:   P. Muthumani1*, R. Meera1, S. Venkataraman1, Murugan1, N. Chidambaranathan2, P. Devi3, B. Kameswari4 and B. Eswarapriya5
1Department of Pharmaceutical Chemistry,
2Department of Pharmacology,
3Department of Pharmacognosy,
4Department of Biochemistry, K. M. College of Pharmacy, Uthangudi, Madurai -625107, Tamilnadu, India , 5Department of Biotechnology,
St. Michael College of Engineering, Sivagangi, Tamilnadu, India
*Corresponding Author
DOI No: Not Available

ABSTRACT:
Para substituted N-aryl anthranilic acid derivatives were synthesized via Ullmann condensation of o-Chlorobenzoic acid with various p-substituted aniline in the presence of cupric oxide (catalyst) and anhydrous potassium carbonate (for removal of hydrogen halide formed during reaction). The synthesized compounds (Ia-Ih) were evaluated the following biological activities Anti-inflammatory, Analgesic activity, Anti-bacterial activity. Organism used: Staphylococcus aureus (MTCC 96) Klebsiella aerogenes (MTCC), E. Coli (MTCC 722) Standard Used: Oflaxacin (10mg/disc)
KEYWORDS:
N-aryl anthranilic acid derivative, Anti inflammatory, Analgesic, Anti bacterial .
Cite:
P Muthumani, R Meera, S Venkataraman, Murugan, N Chidambaranathan, P Devi, B Kameswari, B Eswarapriya. Anti-inflammatory, Analgesic and Antimicrobial Activity of Some Novel Schiff’s bases of N-aryl anthranilic acid Derivatives. Research J. Pharm. and Tech.3 (3): July-Sept. 2010; Page 740-743.
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