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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   3

Issue No. :  2

Year :  2010

Pages :   417-419

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Antagonistic Activity of Soil Fungal Metabolite against Streptococcus mutans Strains



Address:   Pranay Jain1* and Ram Kumar Pundir2
2Kurukshetra Institute of Technology and Management, Bhor Saidan, Kurukshetra-136119
1University Institute of Engineering and Technology Kurukshetra University, Kurukshetra-136119
*Corresponding Author
DOI No: Not Available

ABSTRACT:
In the present investigation, a soil fungus was isolated by using serial dilution agar plate technique and screened for its antagonistic activity against the three Streptococcus mutans strains following the overlay culture plate technique and agar well diffusion method. The antagonistic activity of fungal metabolite was compared with commercially available drug gentamycin, which was used as positive control. Identified fungus, Aspergillus terreus showed antagonistic activity in both overlay agar culture plate technique and agar well diffusion method. A. terreus was found to be effective against all the three strains of S. mutans with zone of growth inhibition ranging between 30 and 37mm. The antibacterial activity of fungal metabolite was higher than that of gentamycin and it may be suggested that further research is needed for determining the chemical structure of metabolite which is responsible for bioefficacy and to determine the cytotoxicity and in vivo efficacy against dental caries pathogens before it is used for commercialization purposes.
KEYWORDS:
Antagonistic activity, Aspergillus terreus, gentamycin, Streptococcus mutans.
Cite:
Pranay Jain, Ram Kumar Pundir. Antagonistic Activity of Soil Fungal Metabolite against Streptococcus mutans Strains. Research J. Pharm. and Tech. 3(2): April- June 2010; Page 417-419.
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