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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   3

Issue No. :  2

Year :  2010

Pages :   

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Microwave Mediated Synthesis and Antifungal Activity of Some 5-Benzylidene-2,4-thiazolidinediones



Address:   1Department of Medicinal Chemistry, Mother Teresa College of Pharmacy, Ghatkesar, R.R.Dist., A.P, India. 2Department of Medicinal Chemistry, Nagarjuna University, Guntur, A.P, India.
DOI No: Not Available

ABSTRACT:
A series of 5-benzylidene-2,4-thiazolidinedione derivatives were synthesized by employing microwave irradiation. The synthesis involves microwave irradiation of an aromatic aldehyde with 2,4-thiazolidinedione in sodium acetate/acetic acid in ethanol. The reaction was completed in 15-30 min with 68-82% yields and was environmentally friendly with easy workup. The synthesized compounds were evaluated for antifungal activity.
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