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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   3

Issue No. :  2

Year :  2010

Pages :   619-621

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Microwave Mediated Synthesis and Antifungal Activity of Some 5-Benzylidene-2,4-thiazolidinediones

Address:   M. Srinivas1, K. Satyanarayana1*, S. Kiran Kumar2, N. Sravan Kumar2, V. Ajay2 and N. Kishore2
1Department of Medicinal Chemistry, Mother Teresa College of Pharmacy, Ghatkesar, R.R.Dist., A.P, India.
2Department of Medicinal Chemistry, Nagarjuna University, Guntur, A.P, India.
*Corresponding Author
DOI No: Not Available

A series of 5-benzylidene-2,4-thiazolidinedione derivatives were synthesized by employing microwave irradiation. The synthesis involves microwave irradiation of an aromatic aldehyde with 2,4-thiazolidinedione in sodium acetate/acetic acid in ethanol. The reaction was completed in 15-30 min with 68-82% yields and was environmentally friendly with easy workup. The synthesized compounds were evaluated for antifungal activity.
M Srinivas, K Satyanarayana, S Kiran Kumar, N Sravan Kumar, V Ajay, N Kishore. Microwave Mediated Synthesis and Antifungal Activity of Some 5-Benzylidene-2,4-thiazolidinediones. Research J. Pharm. and Tech. 3(2): April- June 2010; Page 619-621.
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