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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   3

Issue No. :  2

Year :  2010

Pages :   604-609

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Development and Optimization of Mucoadhesive Microsphere of Bovine Insulin



Address:   Shinde AD1*and Bhise SB2
1S.V.P.M.’s Collage of Pharmacy, Malegaon (Bk II), Baramati, Pune, Maharashtra, India. 2Govt. College of Pharmacy, Karad, Dist-Satara, Maharashtra. India
*Corresponding Author
DOI No: Not Available

ABSTRACT:
Bovine Insulin is one of the remarkable anti-diabetic hormonal drug. It is mostly available in the form Vials and administered by parentral Route, which is often complex, difficult, painful and occasionally dangerous. So it was decided to select alternative route of administration hence was nasal route was selected. Bovine Insulin microsphere containg a muchoadhesive polymers Sodium Alginate and Carbapol-934 were prepared by Ionic Gelation technique by utilizing 32 Factorial Drug Design for the Optimization of formulation. Bovine Insulin encapsulated by lyophilization. Mucoadhesive microsphere was evaluated, for microencapsulation efficiency, mucoadhesion study, swelling index, particle size determination and its morphology by using SEM. The Vitro release study for prepared microspheres was done. The prepared microspheres are spherical in shape and multilenthic type and in the range of 10 to 40 µ in a size. The Percentage Encapsulation Efficiency of microspheres varied from 35 % to 86, Mucoadhesion varied from 88 % to 100 %. Photographic and SEM microscopy studies found that the surface of microsphere is rough due to presence of mucoadhesive polymer coat. The release studies show a polymer concentration dependent profile for microspheres.
KEYWORDS:
Bovine Insulin, Mucoadhesive microsphere, Carbapol-934.
Cite:
Shinde AD, Bhise SB. Development and Optimization of Mucoadhesive Microsphere of Bovine Insulin. Research J. Pharm. and Tech. 3(2): April- June 2010; Page 604-609.
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