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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   3

Issue No. :  2

Year :  2010

Pages :   596-599

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Formulation and Evaluation of Ranitidine Hydrochloride Mouth Dissolving Tablet by Effervescent Formulation Technique.



Address:   Vinodh Kumar S Mannur1*, Subhas S Karki2 and Ayaz A Dhada1
1KLE’s College of Pharmacy, Nehrunagar, Belgaum, Karnataka.
2KLE’s College of Pharmacy, Rajaji nagar, Banglore, Karnataka
*Corresponding Author
DOI No: Not Available

ABSTRACT:
Mouth dissolving tablet constitute an innovative dosage form that overcome the problem of swallowing and provides a quick onset of action thus proves to be a user friendly formulation. In view to increase patient compliance and to enhance the bioavailability an attempt was made in the present study to formulate six formulations using two effervescent agents in different concentrations. Sodium bicarbonate and citric acid were used as effervescent agents. Sucralose was employed to mask the bitter taste and orange flavour to impart palatability. All the prepared formulations were evaluated for both precompression and post compression parameters. The study revealed that effervescent formulation approach released about 90% of the drug at the end of 25minutes respectively. The disintegration time for all formulations ranged from 15 to 20 seconds and gave soothing fizz, with excellent mouth feel and good palatability.
KEYWORDS:
Mouth dissolving tablet, effervescence, Ranitidine hydrochloride
Cite:
Vinodh Kumar S Mannur, Subhas S Karki, Ayaz A Dhada. Formulation and Evaluation of Ranitidine Hydrochloride Mouth Dissolving Tablet by Effervescent Formulation Technique. Research J. Pharm. and Tech. 3(2): April- June 2010; Page 596-599.
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