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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   3

Issue No. :  2

Year :  2010

Pages :   592-595

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Studies on the Effect of Hydrophilic Carriers in the Dissolution Rate Enhancement of Poorly Soluble Drug, Bicalutamide

Address:   MV Srikanth1*, GV Murali Mohan Babu2, SA Sunil1, N Sreenivasa Rao1, K Praveen Kumar3 and KV Ramana Murthy1
1 University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530003, India.
2 Unichem Laboratories Ltd, Pilerne Industrial estate, Bardez, Goa-403511, India.
3Hetero Drugs Limited, Hetero Corporate Industrial Estates, Hyderabad-500 082, India
*Corresponding Author
DOI No: Not Available

The purpose of this study was to formulate and evaluate the solid dispersions of bicalutamide, a non- steroidal anti androgen. The role of various water-soluble carriers was studied for dissolution enhancement of a poorly soluble model drug, bicalutamide, using solid dispersion technique. Diverse carriers viz, Povidone K 30, Poloxamer 407 and Gelucire 50/13 were investigated for this purpose. Solid dispersions with Povidone K 30 were prepared by solvent evaporation technique and the dispersions with Poloxamer 407 and Gelucire 50/13 were prepared by fusion process.The results showed that Gelucire 50/13 based solid dispersions exhibited higher dissolution rate than other dispersions. Dissolution studies showed a significant change in the dissolution profile of bicalutamide when dispersed in hydrophilic carriers at varying concentrations, but the maximum drug release was exhibited by the dispersion made with Gelucire 50/13 containing drug: Gelucire 50/13 1:1.The dispersions were characterized by X-ray diffraction. The diffractions exhibited in PXRD reflected the change in the crystalline structure of the bicalutamide in povidone based dispersion, but not in other carrier dispersions.
Solid dispersions, Gelucire 50/13, Povidone k30, Poloxamer 407, Bicalutamide, dissolution rate.
MV Srikanth, GV Murali Mohan Babu, SA Sunil, N Sreenivasa Rao, K Praveen Kumar, KV Ramana Murthy. Studies on the Effect of Hydrophilic Carriers in the Dissolution Rate Enhancement of Poorly Soluble Drug, Bicalutamide. Research J. Pharm. and Tech. 3(2): April- June 2010; Page 592-595.
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