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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   3

Issue No. :  2

Year :  2010

Pages :   562-565

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Validated Spectrophotometric Simultaneous Estimation of Nimesulide and Dicyclomine Hydrocloride in Combined Tablet Dosage Form



Address:   Lokesh Singh1 and Sanju Nanda2
1Swami Keshvanand Institute of Pharmacy, Bikaner (RAJ.) INDIA
2Dept. of Pharmaceutical Sciences, Maharishi Dayanand University, Rohtak (HR.) INDIA
*Corresponding Author
DOI No: Not Available

ABSTRACT:
Two novels, simple, rapid and sensitive spectrophotometric method has been developed for simultaneous estimation of Nimesulide and dicyclomine HCl. The first method involved determination of Nimesulide and Dicyclomine HCl using the Q analysis method and second method involved simultaneous equation method. Nimesulide has absorbance maxima at 300.8 nm, Dicyclomine HCl has absorbance maxima at 217.6 nm and isoabsorptive point is at 232.4 nm in methanol. Linearity was obtained in the concentration ranges 10-100 µg/ml and 900-3000 µg/ml for Nimesulide and Dicyclomine HCl, respectively. These methods were successively applied to pharmaceutical formulation because no interferences from tablet excipients were found. Accuracy and reproducibility of proposed method was statistically validated by recovery studies. The suitability of these methods for the quantitative determination of the compounds was proved by validation.
KEYWORDS:
Nimesulide, Dicyclomine HCl, Simultaneous equation method, Q analysis method, Spectrophotometric.
Cite:
Lokesh Singh, Sanju Nanda. Validated Spectrophotometric Simultaneous Estimation of Nimesulide and Dicyclomine Hydrocloride in Combined Tablet Dosage Form. Research J. Pharm. and Tech. 3(2): April- June 2010; Page 562-565.
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