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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   3

Issue No. :  2

Year :  2010

Pages :   556-558

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Diuretic and Laxative Activities of Methanol Extract of Mimosa pudica Leaves



Address:   Rekha Rajendran1* and S Ruby2
Department of Pharmacognosy and Phytochemistry, Mohamed Sathak A. J. College of Pharmacy, Medavakkam, Chennai - 600 119, Tamil Nadu, India
2 Department of Pharmaceutical Chemistry, Nandha college of pharmacy, India.
*Corresponding Author
DOI No: Not Available

ABSTRACT:
The methanol extract of leaves of Mimosa pudica (Mimosaceae) was screened for diuretic and laxative activities in wistar albino rats. The study suggested that the extract was found to produce significant diuretic as well as laxative activities in dose dependant manner (200 and 400mg/kg p. o.). These activities were comparable with the standard drugs such as Furosemide (10mg/kg p. o.) and Agar-agar (300mg/kg p. o.) respectively. The preliminary phytochemical analysis of methanol extract of leaves of Mimosa pudica revealed the presence of phytoconstituents such as alkaloids, tannins, mucilage and flavonoids. The present study indicates that the observed significant diuretic and laxative activities of Mimosa pudica leaves may be contributed to the phytoconstituents present in it. Further work is in progress to identify the possible mechanisms of action and to identify the lead molecules responsible for diuretic and laxative activities.
KEYWORDS:
Mimosa pudica, diuretic and laxative activities, methanol extract, Furosemide, Agar-agar.
Cite:
Rekha Rajendran, S Ruby. Diuretic and Laxative Activities of Methanol Extract of Mimosa pudica Leaves. Research J. Pharm. and Tech. 3(2): April- June 2010; Page 556-558.
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