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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   3

Issue No. :  2

Year :  2010

Pages :   

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Study on Anti-Ulcer Activity of Daucus carota Juice



Address:   1Dept. of Pharmacology, Sri Padmavathi School of Pharmacy, Thiruchanoor, Tirupathi-517503, A.P, India. 2Department of Pharmaceutics, Annamacharya College of Pharmacy, Rajampeta, Kadapa(dist), A.P, India.
DOI No: Not Available

ABSTRACT:
A number of drugs are now available for treatment of peptic ulcer disease. These drugs are mainly considered the counter acid secretion and cytoprotection by virtue of their effects on mucosal defensive mechanisms. Although these drugs have brought remarkable changes in the ulcer therapy, the efficacy of these drugs is still debatable. Reports on clinical evaluation of these drugs show that there are incidences of relapse, adverse effects and danger to drug interaction during ulcer therapy. The search to find a suitable palliative or curative agent for the treatment of peptic ulcer disease has been extended to dietary fibre. The Main aim of the present study was to verify the claim of Daucus carota as an antiulcer agent, mentioned in traditional system of medicine. Hence, the objective of the present study was to investigate the antiulcer activity of juice of Daucus carota by employing the pylorus ligation method in rats. The group of animals treated with Ranitidine HCl at a dose of 26.57 mg/ kg b.wt, a significant decrease in the acid volume (13.5 ml) and increase in the gastric pH (6) was noted. Group receiving D. carota at a dose of 1 g/ kg. b. wt. a significant decrease in the acid volume (5.96 ml) and increase in gastric pH (6) was observed when compared with the control animals. The anti-ulcer activity was observed by using the ulcer index values such as control (14.9), standard (5.15) and test samples (3.833). By on the observation of ulcer index values the prepared Daucus carota juice having the best anti-ulcer activity compared with standard sample.
KEYWORDS:
Daucus Carota, , Gastric fluid, Ranitidine Hcl, Saline water, Mean Ulcer Number, Mean Ulcer Score, Mean Ulcer percentage, ulcer index.
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