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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   3

Issue No. :  2

Year :  2010

Pages :   543-546

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Formulation and Optimization of Orodispersible Tablets of Olanzapine



Address:   NKD Devi*, AP Rani, BR Madhavi, BS Mrudula and A Swetha
K.V.S.R Siddhartha College of Pharmaceutical Sciences, Vijayawada-10.
*Corresponding Author
DOI No: Not Available

ABSTRACT:
In the present study, fast dissolving tablets of Olanzapine were prepared by Roll compaction technique with a view to enhance patient compliance. Six formulations were prepared for the optimization of concentrations of disintegrant and binder. The formulations were developed with the aim of having balance over the hardness and disintegration time of the tablets. The prepared batches of tablets were evaluated for hardness, friability, thickness and disintegration time. Based on in vitro dispersion formulations were tested for the in vitro drug release pattern in 0.1 N Hcl. The formulations were checked for their stability at 400/75% relative humidity for 6 months. Among the formulations prepared F-5 emerged as the overall best formulation .The drug release was found to be comparable to the marketed formulation. Short term stability studies on the formulations indicated that there was no change in drug content and in-vitro dispersion time.
KEYWORDS:
Fast dissolving tablets, Olanzapine, L-Hpc II, croscarmellose sodium.
Cite:
NKD Devi, AP Rani, BR Madhavi, BS Mrudula, A Swetha. Formulation and Optimization of Orodispersible Tablets of Olanzapine. Research J. Pharm. and Tech. 3(2): April- June 2010; Page 543-546.
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