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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   3

Issue No. :  2

Year :  2010

Pages :   530-534

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Formulation and Evaluation of Loperamide Hydrochloride Mouth Dissolving Tablet by Using Super Disintegrants



Address:   Venkatalakshmi R*1, Sasikala C1 and SP Silambarasan2
1Shri Vishnu College of Pharmacy, Vishnupur, West Godavari, Bhimavaram – 534 202, Andhra Pradesh, India.
2Dep. of Pharmaceutical Analysis, Adhiparasakthi College of Pharmacy, Melmaruvathur, (T.N.), India- 603 319.
*Corresponding Author
DOI No: Not Available

ABSTRACT:
Loperamide hydrochloride 180 mg mouth dissolving tablet was prepared by using super disintegrants such as Sodium starch glycolate, Croscarmellose Sodium, Crospovidone at various concentration and Sucralose, aspartame used as sweetening agent. The excipients were used for this study was based on the compatibility studies. All the formulations were prepared by direct compression method. Among all the formulations Crospovidone at 10 mg/tablet gives 98 % drug release at 12th minute by UV method. It was considered as optimized batch. The optimized batch was passes all the evaluation parameters and stability studies .The final formulation were packed in blister package.
KEYWORDS:
Loperamide hydrochloride, Sodium starch glycolate, Croscarmellose sodium, Crospovidone.
Cite:
Venkatalakshmi R, Sasikala C, SP Silambarasan. Formulation and Evaluation of Loperamide Hydrochloride Mouth Dissolving Tablet by Using Super Disintegrants. Research J. Pharm. and Tech. 3(2): April- June 2010; Page 530-534.
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