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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   3

Issue No. :  2

Year :  2010

Pages :   

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Preparation and Characterisation of Alginate Coated Chitosan Microspheres for Bacterial Vaccines.

Address:   KMCH College of Pharmacy, Kalapatti Road, Coimbatore-641 048, Tamil Nadu, India.
DOI No: Not Available

Tetanus toxoids vaccine is widely used to prevent tetanus.As it has a short biological half-life, a long acting tetanus toxoids formulation is desirable to improve patient compliance. The chitosan microspheres were prepared by an emulsion polymerization method using glutaraldehyde as the crosslinking agent. All microspheres were spherical and smooth with the mean particle size in the range of 30–38 μm. Drug release from the chitosan microspheres displayed a biphasic pattern characterized by an initial fast release, followed by a slower release. The released amount was decreased with an increase in the glutaraldehyde concentration. The time required for complete degradation of microspheres was increased from 144 to 264 h when the glutaraldehyde concentration increased from 0.1 to 0.7 ml. Biodistribution studies indicated that the degree of uptake by the M-cells of the peyer’s patches in the gut was higher than that of the other organs. All these results demonstrated that tetanus toxoids loaded chitosan microspheres can be used for passive M-cell targeting.
Chitosan microsphere; Tetanus toxoid; mucosal immunization; Controlled-release
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