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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   3

Issue No. :  2

Year :  2010

Pages :   494-499

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Sustained Release Mucoadhesive Tablets of Metoprolol Succinate for Buccal Administration.



Address:   Pathan AM*, Channawar MA, Bakde BV, Gawande SR, Sapkal SR, Chandewar AV and KS Bombatkar
Dept. of Pharmaceutics, Pataldhamal Wadhwani College of Pharmacy, Yavatmal – 445001 Maharashtra, India.
*Corresponding Author
DOI No: Not Available

ABSTRACT:
The buccal mucosa has been investigated for local and systemic delivery of therapeutic peptides and other drugs that are subjected to first-pass metabolism or are unstable within the rest of the gastrointestinal tract. Metoprolol Succinate is subjected to first-pass effect, therefore formulation of buccal-adhesive dosage form can circumvent this effect. In the present investigation, an attempt was made to developed buccoadhesive sustained release tablet of Metoprolol succinate. Total six formulations were prepared with varying the concentration of mucoadhesive polymers. Mucoadhesive polymers such as HPMC, Carbopol 934P were used to formulate such dosage form with magnesium stearate as a lubricant. The tablets were prepared by direct compression method & evaluated with regards to the parameters for drug content, hardness, friability, and weight variation, mucoadhesive strength, swelling index & dissolution studies. In the formulation batches, that contain Carbopol 934 P, with HPMC K4M in different ratio, in 1:2 ratios shows maximum swelling index, bioadhesive force was found to decrease with decrease in proportion of HPMC K4M. In IR spectroscopy, similar peaks were obtained of pure drug and F4 batch tablet that indicate there is no any physical or chemical interaction between drug, polymer & excipients. The maximum % cumulative drug release of the loaded drug was found to be in F4 formulation batch as 94.9 % after 8 h in vitro in saliva fluid pH 6.2 while they released about 96 %.of their content after the same time in phosphate buffer pH 6.8
KEYWORDS:
Buccal Delivery, Buccal Mucoadhesive Tablet, Metoprolol Succinate, Mucoadhesion.
Cite:
Pathan AM, Channawar MA, Bakde BV, Gawande SR, Sapkal SR, Chandewar AV, KS Bombatkar. Sustained Release Mucoadhesive Tablets of Metoprolol Succinate for Buccal Administration. Research J. Pharm. and Tech. 3(2): April- June 2010; Page 494-499.
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