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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   3

Issue No. :  2

Year :  2010

Pages :   478-482

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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A Novel Sustained Release Swellable Bioadhesive Floating Gastroretentive Drug Delivery System for Tuberculosis



Address:   T Udayakumar* and M Mohammed Hussain
Department of Pharmaceutics, C.L.Baid Metha College of pharmacy, Chennai-97, Tamil Nadu India.
*Corresponding Author
DOI No: Not Available

ABSTRACT:
Controlled release formulations of Rifampicin of about 28 formulations developed using combination of psyllium husk, Carbopol-934, Sodium Carboxy methyl cellulose, Chitosan-H, Sodium alginate, polymethacrylic acid ethyl acrylate and Basil seed using suitable different concentration. Initially the granules were prepared by wet granulation method and evaluated for bulk density (0.494-0.610); tapped density (0.521-0.694), Carr’s index (9.81-15.01), Angle of repose (200-300), drug content was estimated. The granules were punched with single punch machine and evaluated for Hardness, Friability and Weight variation were determined. The Buoyancy and dimensional stability were determined to asses the best formulation for the further studies after invitro dissolution study. Amongst five selected formulation from the Buoyancy and invitro dissolution the best one was selected by the evaluation of muco adhesive property of the formulation using sheep stomach tissues. The selected best formulation is further studied for invivo bioavailability and floating property analysed by X-ray in the rabbit stomach using radiographic imaging technique. Finally concluded from the results that formulation using psyllium husk is the best polymer for gastroretentive drug delivery system of Rifampicin.
KEYWORDS:
Gastro retentive system, Rifamicin, psyllium husk, in vivo and in vitro evaluation.
Cite:
T Udayakumar, M Mohammed Hussain. A Novel Sustained Release Swellable Bioadhesive Floating Gastroretentive Drug Delivery System for Tuberculosis. Research J. Pharm. and Tech. 3(2): April- June 2010; Page 478-482.
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