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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   3

Issue No. :  2

Year :  2010

Pages :   

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Formulation and Evaluation of Controlled Release Drug Delivery System Containing Water Soluble Drug.



Address:   Bharati Vidyapeeth’s College of Pharmacy, CBD Belapur, Sector-8, Navi Mumbai-400 614, India.
DOI No: Not Available

ABSTRACT:
The objective of the present study was to develop controlled release tablet of water soluble drug (X) which can release the drug up to time of 12 hrs in predetermined rate. The drug release for extended duration, particularly for highly water soluble drug using a hydrophilic matrix system is restricted because of the rapid diffusion of the dissolved drug though the hydrophilic network. For such drug with high water solubility hydrophobic polymers are suitable, along with a hydrophilic matrix for developing sustained release dosage forms. Therefore in this study both the hydrophilic and hydrophobic polymer was used as matrix material to obtain a desirable drug release, patient compliance and cost–effectiveness. Hence in the present study work an attempt has been made to develop controlled release matrix tablet using hydrophobic and hydrophilic polymers. Matrix materials such as (HPMC) hydroxyl propyl methyl cellulose, hydroxyl propyl cellulose (HPC) and ethyl cellulose (EC), Na CMC, hydrogenated castor oil are tried. The in vitro drug release study and optimization studies revealed that low concentration of HPMC and high concentration of Ethyl Cellulose was able to control the simultaneous release of water soluble drug for 12 hours. Optimization was done using 32factorial design. The in vitro release data followed higuchi equation or matrix model, respectively. In conclusion, the in vitro release profile and the mathematical models indicate that release of drug can be effectively controlled from a single tablet using HPMC and EC matrix system.
KEYWORDS:
Water soluble drug X, Hydrophobic and Hydrophilic Polymers, Optimization, In-vitro release mechanisms.
Cite:
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