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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   3

Issue No. :  2

Year :  2010

Pages :   319-326

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Nanoemulsions - Approaching Thermodynamic Stability



Address:   Uma Sankari K*, Alagusundaram M, G Krishna Sahithi, C Madhu Sudhana Chetty, S Ramkanth, S Angalaparameswari and TS Mohammed Saleem
Dept. of Pharmaceutics, Annamacharya College of pharmacy, Rajampet, Kadappa-District, Andhrapradesh, India.
*Corresponding Author
DOI No: Not Available

ABSTRACT:
Nanoemulsions are part of a broad class of multiphase colloidal dispersions. In the world of nanomaterials, Nanoemulsions hold great promise as useful dispersions of deformable nanoscale droplets that can have flow properties ranging from liquid to highly solid and optical properties ranging from opaque to nearly transparent due to their small droplet sizes posses stability against sedimentation or creaming with Ostwald ripening forming the main mechanism of nanoemulsion breakdown. The long-term physical stability of nanoemulsions with no apparent flocculation or coalescence makes them unique and they are referred to as ‘Approaching Thermodynamic Stability’. Nanoemulsions can be prepared by use of high-pressure homogenizers, use of the low-energy emulsification method at constant temperature or application of the phase inversion temperature (PIT) concept. The compositional flexibility of Nanoemulsions offers a wide range in pharmaceutical applications. This review article emphasizes the formation, properties, mechanism of emulsification and characterization which enable a wide range of interdisciplinary researchers to enter the imperative field of nanoemulsions.
KEYWORDS:
Nanoemulsions, Ostwald ripening, Thermodynamic stability, Phase inversion temperature.
Cite:
Uma Sankari K, Alagusundaram M, G Krishna Sahithi, C Madhu Sudhana Chetty, S Ramkanth, S Angalaparameswari, TS Mohammed Saleem. Nanoemulsions - Approaching Thermodynamic Stability. Research J. Pharm. and Tech. 3(2): April- June 2010; Page 319-326.
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