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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   3

Issue No. :  2

Year :  2010

Pages :   458-460

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Formulation and Evaluation of Lacidipine Tablets Employing Lacidipine – Starch Phosphate Binary Systems



Address:   Prasanthi NL* and Rama Rao N
Chalapathi Institute of Pharmaceutical Sciences, Lam, Guntur- 522034 Andhra Pradesh, India.
*Corresponding Author
DOI No: Not Available

ABSTRACT:
The objective of the study is to formulate and evaluate lacidipine tablets employing lacidipine-starch phosphate binary systems. Binary systems of lacidipine in starch phosphate were prepared in different drug to carrier ratios. Lacidipine tablets were formulated employing lacidipine-starch phosphate binary systems and their corresponding physical mixtures. The compressed tablets were evaluated for various tablet characteristics including dissolution rate and efficiency. Marked increase in the dissolution rate and efficiency of lacidipine was observed with tablets of binary systems in comparison to tablets formulated with physical mixture and pure drug. Dissolution of lacidipine from the binary systems obeyed first order kinetics.
KEYWORDS:
Starch phosphate, Lacidipine, solid binary systems, tablets.
Cite:
Prasanthi NL, Rama Rao N. Formulation and Evaluation of Lacidipine Tablets Employing Lacidipine – Starch Phosphate Binary Systems. Research J. Pharm. and Tech. 3(2): April- June 2010; Page 458-460.
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