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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   3

Issue No. :  2

Year :  2010

Pages :   452-454

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Design and Evaluation of Floating Drug Delivery System of Furosemide.



Address:   Varma MM*, Suneetha S and Raju DB
Shri Vishnu College of Pharmacy, Vishnupur,Bhimavaram-534202, A.P.
*Corresponding Author
DOI No: Not Available

ABSTRACT:
Controlled release gastroretentive dosage forms enable controlled and continuous input of the drug to the upper parts of gastrointestinal tract and improve the bioavailability of drug that is characterized by narrow absorption window .Floating drug delivery systems of furosemide were formulated using various concentrations of polymers such as HPMC K4M,HPMC K15M,HPMC K100M,ethyl cellulose and effervescing agents sodium bicarbonate and citric acid. The formulations were evaluated for floating properties and in vitro drug release studies. The floating tablets fulfilled the official specifications of weight variation, hardness, friability and drug content. The formulated tablets showed controlled release of the drug for a period of 10 hrs. The drug release from the floating tablets was found to be non fickian diffusion obeying zero order kinetics.
KEYWORDS:
Furosemide, Floating tablets, HPMC, Ethyl cellulose.
Cite:
Varma MM, Suneetha S, Raju DB. Design and Evaluation of Floating Drug Delivery System of Furosemide. Research J. Pharm. and Tech. 3(2): April- June 2010; Page 452-454.
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