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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   3

Issue No. :  2

Year :  2010

Pages :   

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Analgesic Activity of Thuja orientalis Leaves



Address:   1Dept. of Pharmacognosy, Sanjivani College of Pharmaceutical Education and Research, Kopergaon-423603 2Department of Pharmacognosy, Pravara Rural College of Pharmacy, Pravaranagar, A/P-Loni (413 736), Tal- Rahata, Dist-Ahmednagar. (M.S.)
DOI No: Not Available

ABSTRACT:
Present study reports analgesic activity of petroleum ether, chloroform, methanolic and aqueous extract of leaves of Thuja orientalis. Hot plate and tail immersion methods were used for evaluation of central analgesic activity and acetic acid induced writhing model was used for evaluation of peripheral analgesic activity. Hot plate acetic acid induced writhing model was used for evaluation of central analgesic activity as well as peripheral analgesic activity. Results indicate that petroleum ether extract of leaves at 50 mg/kg, i.p. dose produced a significant increase in reaction time (P<0.05) in tail immersion method and increased in response latency period (P<0.05) in hot plate method, against standard drug pentazocin. Aqueous extract of leaves of Thuja orientalis significantly (P<0.05) attenuated the number of writhing when compared to standard drug paracetamol in acetic acid induced writhing model.
KEYWORDS:
Thuja orientalis, hot plate method, tail immersion method, acetic acid induced writhing model.
Cite:
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