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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   3

Issue No. :  2

Year :  2010

Pages :   

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Anti-Inflammatory and Anti-Nociceptive Activity of Adiantum capillus



Address:   1National Institute of Ayurvedic Pharmaceutical Research, Patiala, India 2Govt. Polytechnic College for Girls, Patiala, India 3Akal College of Pharmacy and Technical Education, Mastuana Sahib, Sangrur, India
DOI No: Not Available

ABSTRACT:
The present study was designed to evaluate both anti-inflammatory and antinociceptive activity of the ethanolic extract of dried leaves of Adiantum capillus (ACEE), using the Carrageenan-induced paw edema method in rats and Tail-flick method in mice, respectively, at various dose levels. The maximum anti-inflammatory effect of the extract was found to be at 300 mg/kg in carrageenan test and this effect was equivalent to phenylbutazone (PBZ) (80 mg/kg, orally) (p<0.05). The extract also demonstrated marked antinociceptive activity at a dose of 300 mg/kg and the effect was comparable to that of standard drug, Ibuprofen (100 mg/kg orally) (p<0.05). The results of this study have established the anti-inflammatory activity and antinociceptive activity of leaf extracts of Adiantum capillus.
KEYWORDS:
Adiantum capillus, Paw edema method, Adiantaceae, Tail-flick method.
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