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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   3

Issue No. :  2

Year :  2010

Pages :   432-434

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Anti-Inflammatory and Anti-Nociceptive Activity of Adiantum capillus



Address:   Vikas Gupta1*, Parveen Bansal1, Pawan Kumar2 and Gurpreet Kaur3
1National Institute of Ayurvedic Pharmaceutical Research, Patiala, India
2Govt. Polytechnic College for Girls, Patiala, India
3Akal College of Pharmacy and Technical Education, Mastuana Sahib, Sangrur, India
*Corresponding Author
DOI No: Not Available

ABSTRACT:
The present study was designed to evaluate both anti-inflammatory and antinociceptive activity of the ethanolic extract of dried leaves of Adiantum capillus (ACEE), using the Carrageenan-induced paw edema method in rats and Tail-flick method in mice, respectively, at various dose levels. The maximum anti-inflammatory effect of the extract was found to be at 300 mg/kg in carrageenan test and this effect was equivalent to phenylbutazone (PBZ) (80 mg/kg, orally) (p<0.05). The extract also demonstrated marked antinociceptive activity at a dose of 300 mg/kg and the effect was comparable to that of standard drug, Ibuprofen (100 mg/kg orally) (p<0.05). The results of this study have established the anti-inflammatory activity and antinociceptive activity of leaf extracts of Adiantum capillus.
KEYWORDS:
Adiantum capillus, Paw edema method, Adiantaceae, Tail-flick method.
Cite:
Vikas Gupta, Parveen Bansal, Pawan Kumar, Gurpreet Kaur. Anti-Inflammatory and Anti-Nociceptive Activity of Adiantum capillus. Research J. Pharm. and Tech. 3(2): April- June 2010; Page 432-434.
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