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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   3

Issue No. :  1

Year :  2010

Pages :   

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Analgesic Effects of Fruits of Silybum marianum L. Gaertn



Address:   1Department of Pharmaceutical Sciences, Gurusar Sadhar, Ludhiana (Punjab). 2Govt. Institute of Pharmaceutical and Engineering Sciences, Amritsar (Punjab).
DOI No: Not Available

ABSTRACT:
The present study was designed to investigate the analgesic effects of fruits of Silybum marianum L. Gaertn. The ethylacetate and ethanol extracts of Silybum marianum L. Gaertn fruits showed dose-dependent and significant (P<0.05) increase in pain threshold in tail–immersion test. Moreover, both the extracts (100-200mg/kg) exhibits a dose–dependent inhibition of writhing and also showed a significant (P<0.001) inhibition of both phases of formalin pain test. The phytochemical screening of the extract showed the presence of flavonolignans, flavonoids, fixed oils and proteins.
KEYWORDS:
Analgesic activity, Formalin pain test, Tail immersion test, Silybum marianum
Cite:
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