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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   3

Issue No. :  1

Year :  2010

Pages :   92-94

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Analgesic Effects of Fruits of Silybum marianum L. Gaertn



Address:   Manpreet Kaur1* and Harinder Kaur2
1Department of Pharmaceutical Sciences, Gurusar Sadhar, Ludhiana (Punjab).
2Govt. Institute of Pharmaceutical and Engineering Sciences, Amritsar (Punjab).
*Corresponding Author
DOI No: Not Available

ABSTRACT:
The present study was designed to investigate the analgesic effects of fruits of Silybum marianum L. Gaertn. The ethylacetate and ethanol extracts of Silybum marianum L. Gaertn fruits showed dose-dependent and significant (P<0.05) increase in pain threshold in tail–immersion test. Moreover, both the extracts (100-200mg/kg) exhibits a dose–dependent inhibition of writhing and also showed a significant (P<0.001) inhibition of both phases of formalin pain test. The phytochemical screening of the extract showed the presence of flavonolignans, flavonoids, fixed oils and proteins.
KEYWORDS:
Analgesic activity, Formalin pain test, Tail immersion test, Silybum marianum.
Cite:
Manpreet Kaur, Harinder Kaur. Analgesic Effects of Fruits of Silybum marianum L. Gaertn. Research J. Pharm. and Tech. 3(1): Jan. - Mar. 2010; Page 92-94.
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