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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   3

Issue No. :  1

Year :  2010

Pages :   82-86

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Validated Method for the Quantification of Sodium Azide in a Range of ‘Sartan’ Drugs by Ion Chromatography



Address:   Dharmendra Kumar Kushwah*, Prakash Yashwant Kohle, Rajesh D Joshi, Bakul Rajyaguru, Rajeev Pandey and Brajesh Vishwakarma
CTX Life sciences Pvt. Ltd., 251-252, Sachin Magdalla Road, Sachin, Surat, Gujarat-394230, India
*Corresponding Author
DOI No: Not Available

ABSTRACT:
Sodium azide is harmful to our body organs specially heart and brain, because heart and brain use a lot of oxygen, Sodium azide prevents the cells of the body from using oxygen. For the determination of content of free Sodium azide in a range of sartan drug, a method has been developed and validated on Ion Chromatograph (IC). Strongly basic anion exchange resin column (250 x 4.0) mm is used with 50 x 4.0 mm guard column of same stationary phase. Mobile phase consisted of 2.8 ml of Sulphuric acid per litre of water. The method is validated for its Specificity, Precision, Accuracy, Linearity Ruggedness and Robustness. Sodium azide (as azide) is linear from 0.082µg/ml to 0.61 µg/ml, with Correlation Coefficient 0.99933. Limit of quantitation of the method is 0.082 µg/ml and Limit of Detection is 0.041 µg/ml.
KEYWORDS:
Sodium azide, IC, Ion exchange column, Limit of Quantitation, and Limit of Detection.
Cite:
Dharmendra Kumar Kushwah, Prakash Yashwant Kohle, Rajesh D Joshi, Bakul Rajyaguru, Rajeev Pandey, Brajesh Vishwakarma. Validated Method for the Quantification of Sodium Azide in a Range of ‘Sartan’ Drugs by Ion Chromatography. Research J. Pharm. and Tech. 3(1): Jan.-Mar. 2010; Page 82-86.
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