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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   3

Issue No. :  1

Year :  2010

Pages :   257-259

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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In-Vitro and In-Vivo Correlation of Marketed Formulation of Nimesulide



Address:   Kuldeep Malodia1*, Sunil Kumar1, Pankaj Rakha2, SK Singh3 and DN Mishra3
1Lord Shiva College of Pharmacy, Sirsa-125055
2Rajendra Institute of Technology and Sciences, 4th Mile Stone, Hisar Road, Sirsa
3Guru Jambheshwar University of Science and Technology, Hisar
*Corresponding Author
DOI No: Not Available

ABSTRACT:
In vitro Dissolution is an important Quality control tool, provided it is based on a meaningful in vitro- in vivo correlation (IVIVC). Such Dissolution test can prove as a surrogate to extensive, expensive and time consuming invivo bioavailability testing on human. In the present study we had made an attempt to establish in vitro data protocol for in vivo performance of the drug. In order to established IVIVC we selected formulation of nimesulide i. e. nimesulide plain 100 mg for accurate use of data from both the fasted and fed state IVIVC.
KEYWORDS:
IVIVC, Nimesulide, Dissolution
Cite:
Kuldeep Malodia, Sunil Kumar, Pankaj Rakha, SK Singh, DN Mishra. In-Vitro and In-Vivo Correlation of Marketed Formulation of Nimesulide. Research J. Pharm. and Tech. 3(1): Jan.-Mar. 2010; Page 257-259.
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