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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   3

Issue No. :  1

Year :  2010

Pages :   

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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In-Vitro and In-Vivo Correlation of Marketed Formulation of Nimesulide



Address:   1Lord Shiva College of Pharmacy, Sirsa-125055 2Rajendra Institute of Technology and Sciences, 4th Mile Stone, Hisar Road, Sirsa 3Guru Jambheshwar University of Science and Technology, Hisar
DOI No: Not Available

ABSTRACT:
In vitro Dissolution is an important Quality control tool, provided it is based on a meaningful in vitro- invivo correlation (IVIVC). Such Dissolution test can prove as a surrogate to extensive, expensive and time consuming invivo bioavailability testing on human. In the present study we had made an attempt to establish in vitro data protocol for in vivo performance of the drug. In order to established IVIVC we selected formulation of nimesulide i.e. nimesulide plain 100 mg for accurate use of data from both the fasted and fed state IVIVC.
KEYWORDS:
IVIVC, Nimesulide, Dissolution
Cite:
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