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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   3

Issue No. :  1

Year :  2010

Pages :   251-253

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Simultaneous Determination of Cefuroxime Axetil and Potassium Clavulanate in Tablet Dosage Form by Spectrophotometry



Address:   Mahima R Sengar, Santosh V Gandhi*, Vivek Rajmane, Upasana P Patil and Bhargav B Gandhi
Dept. of Pharmaceutical Analysis, A.I.S.S.M.S. College of Pharmacy, Kennedy Road, Near R.T.O., Pune - 411 001. *Corresponding Author
DOI No: Not Available

ABSTRACT:
Two accurate, precise, sensitive and economical procedures for simultaneous estimation of Cefuroxime Axetil and Potassium clavulanate in tablet dosage form have been developed. The methods employed were Absorbance correction method (I) and first order derivative spectroscopic method (II). The first method employs wavelength 277 nm for direct estimation of Cefuroxime axetil where Potassium clavulanate shows nil absorbance. Estimation of Potassium clavulanate is carried out after correction for absorbance of Cefuroxime axetil at 218 nm. The second method is based on first order derivative spectroscopy. Wavelengths 230 nm and 300 nm were selected for the estimation of the Potassium clavulanate and Cefuroxime axetil respectively. Both the drugs obey Beer’s law in the concentration range 5-50 mcg/mL. The results of analysis have been validated statistically and by recovery studies.
KEYWORDS:
Cefuroxime axetil, Potassium clavulanate, Absorbance correction method, First order derivative spectroscopic method.
Cite:
Mahima R Sengar, Santosh V Gandhi, Vivek Rajmane, Upasana P Patil, Bhargav B Gandhi. Simultaneous Determination of Cefuroxime Axetil and Potassium Clavulanate in Tablet Dosage Form by Spectrophotometry. Research J. Pharm. and Tech. 3(1): Jan.-Mar. 2010; Page 251-253.
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