List of Refereed Journals published by UGC, New Delhi on 28-03-2017-- AJRC (Sr. No.-1025); AJM (Sr. No.-2497); RJET (Sr. No.-7220); RJPP (Sr. No.- 7232): RJPPD (Sr. No.- 7234); RJPT (Sr. No.-7235) (19-Apr-2017)        | List of Refereed Journals published by UGC, New Delhi on 11-01-2017-- Research Journal of Pharmacy and Technology (Sr. No.-275); Asian Journal of Management (Sr. No.-3986); Asian Journal of Research in Chemistry (Sr. No.-4008); Research Journal of Engineering and Technology (Sr. No.-31787); Research (22-Jan-2017)        |

Journal :   Research Journal of Pharmacy and Technology

Volume No. :   3

Issue No. :  1

Year :  2010

Pages :   

ISSN Print :  0974-3618

ISSN Online :  0974-360X


Registration

Allready Registrered
Click to Login

Development of Time Programmed Pulsincap System for Chronotherapeutic Delivery of Diclofenac Sodium



Address:   1Sri.K.V.College of Pharmacy, Department of Pharmaceutics, M.G. Road, Chickballapur, 562101. 2Dr. H.L.T.College of Pharmacy, Department of Pharmaceutics, Kengal, Channapatna. 571502. 3T.V.M.College of Pharmacy, Department of Pharmaceutics, Gandhi Nagar,
DOI No: Not Available

ABSTRACT:
The objective of this study was to develop and evaluate a time or site specific pulsatile drug delivery system. The basic design consists of an insoluble hard gelatin capsule body, filled with eudragit microcapsules of Diclofenac sodium and sealed with a hydrogel plug. The entire capsule was enteric coated, so that the variability in gastric emptying time can be overcome and a colon-specific release can be achieved. The diclofenac microcapsules were prepared in four batches, with Eudragit RS-100 by varying drug to polymer ratio and evaluated for the particle size, drug content and in vitro release profile and from the obtained results; one better formulation was selected for further fabrication of Pulsatile capsule. Different grades of HPMC hydrogel polymer were used as plugs, to maintain a suitable lag period and it was found that the drug release was controlled by the proportion of polymers used. The entire capsule was enteric coated by using eudragit L-100, so that colon specific release can be achieved. In-vitro release studies of pulsincap system revealed that colon specific release has been achieved, increasing the hydrophilic polymer content resulted in delayed release of diclofenac sodium from microcapsule.
KEYWORDS:
Pulsatile; Colon-specific; Eudragit microcapsules;
Cite:
Not Available
[View HTML]     



Visitor's No. :   173284