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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   3

Issue No. :  1

Year :  2010

Pages :   234-238

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Development of Time Programmed Pulsincap System for Chronotherapeutic Delivery of Diclofenac Sodium



Address:   Harshitha R1, Pavan Kumar Potturi1, Ramesh R2, RajKumar N2, Nagaraja G2 and Murthy PNVN3
1Sri.K.V.College of Pharmacy, Department of Pharmaceutics, M.G. Road, Chickballapur, 562101.
2Dr. H.L.T.College of Pharmacy, Department of Pharmaceutics, Kengal, Channapatna. 571502.
3T.V.M.College of Pharmacy, Department of Pharmaceutics, Gandhi Nagar, Bellary, 583103.
*Corresponding Author
DOI No: Not Available

ABSTRACT:
The objective of this study was to develop and evaluate a time or site specific pulsatile drug delivery system. The basic design consists of an insoluble hard gelatin capsule body, filled with eudragit microcapsules of Diclofenac sodium and sealed with a hydrogel plug. The entire capsule was enteric coated, so that the variability in gastric emptying time can be overcome and a colon-specific release can be achieved. The diclofenac microcapsules were prepared in four batches, with Eudragit RS-100 by varying drug to polymer ratio and evaluated for the particle size, drug content and in vitro release profile and from the obtained results; one better formulation was selected for further fabrication of Pulsatile capsule. Different grades of HPMC hydrogel polymer were used as plugs, to maintain a suitable lag period and it was found that the drug release was controlled by the proportion of polymers used. The entire capsule was enteric coated by using eudragit L-100, so that colon specific release can be achieved. In-vitro release studies of pulsincap system revealed that colon specific release has been achieved, increasing the hydrophilic polymer content resulted in delayed release of diclofenac sodium from microcapsule.
KEYWORDS:
Pulsatile; Colon-specific; Eudragit microcapsules.
Cite:
Harshitha R, Pavan Kumar Potturi, Ramesh R, RajKumar N, Nagaraja G, Murthy PNVN. Development of Time Programmed Pulsincap System for Chronotherapeutic Delivery of Diclofenac Sodium. Research J. Pharm. and Tech. 3(1): Jan.-Mar. 2010; Page 234-238.
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