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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   3

Issue No. :  1

Year :  2010

Pages :   

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Study of Effect of Solubility of Drug on the Release Behavior from Buccal Films of a Hydrophilic Polymer



Address:   1Department of Pharmaceutics, PRIST College of Pharmacy, PRIST University, Abishekapakkam , Puducherry- 605 007, India. 2Institute of Pharmaceutical technology, Annamalai University Chidambaram, Tamilnadu, India. 3SRM College of Pharmacy, SRM Universit
DOI No: Not Available

ABSTRACT:
The objective of the present work is to compare the solubility profile of a water soluble drug and a water insoluble drug and thereby study their release behavior from a buccal film containing the same hydrophilic polymer HPMC in association with PEG400. The two drugs selected for the study are diclofenac sodium which is sparingly water soluble and ibuprofen which is water insoluble. The drug’s solubility profile from the formulation into buccal mucosa for absorption was studied. The films exhibited satisfactory physical and mechanical properties like patch thickness in mm, folding endurance, percentage increase in weight, surface pH, percentage swellability. Diffusion study indicates that release can be sustained for a period of upto 3-6 hours. This study concludes that mucoadhesive patches can be used as a promising novel drug delivery system by considering drug solubility profile as a major criteria in drug designing.
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