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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   3

Issue No. :  1

Year :  2010

Pages :   161-164

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Synthesis of 2-Substituted Pyrimidines and Evaluation of Its Pharmacological Activities



Address:   R Murugan*, R Arjunan, M Austin, J Belsen, P Vijin and S Tom
Annamalai University, Annamalai Nagar, Chidambaram (India).
*Corresponding Author
DOI No: Not Available

ABSTRACT:
It is the continuation of our search for new substituted pyrimidines based on analgesic, CNS depressant sedative and hypnotic activity. A mixture of acetanilide, aromatic aldehyde in ethanol, Sodium hydroxide to give (Compound-I) N-phenyl 3- phenyl-2-propenamide. Compound-I on reaction with ethanol, Sodium hydroxide, urea to give (Compound-II) 6-phenyl amino-4phenyl-2-hydroxy pyrimidine. The compound-I react with Sodium hydroxide, thiourea, ethanol to give (Compound-III) 6-phenyl amino 4-phenyl- 2-mercapto pyrimidine. The synthesized compounds were evaluated for their analgesic and depressant activities compared to Diclofenac and Diazepam as positive control. Detailed synthesis, spectroscopic and toxicity data were studied and reported.
KEYWORDS:
Pyrimidine Derivatives, Synthesis, Analgesic, Depressant.
Cite:
R Murugan, R Arjunan, M Austin, J Belsen, P Vijin, S Tom. Synthesis of 2-Substituted Pyrimidines and Evaluation of Its Pharmacological Activities. Research J. Pharm. and Tech. 3(1): Jan. - Mar. 2010; Page 161-164.
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