Journal :   Research Journal of Pharmacy and Technology

Volume No. :   3

Issue No. :  1

Year :  2010

Pages :   154-156

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Synthesis and Antimicrobial Evaluation of Some 2- (Piperazinomethylamino) Imidazole Derivatives

Address:   SP Wate, AN Ingale and PS Tarte*
Sharad Pawar College of Pharmacy, Wandongari, Hingana Road, Nagpur-441110 (M. S.)
*Corresponding Author
DOI No: Not Available

Benzoin was reacted with aminomethamine in ethanol to yield 2-amino-4,5-diphenylimidazole, which on further reaction with dichloromethane in presence of ethanolic potassium hydroxide yielded 2-(chloromethylamino)-4,5-diphenylimidazole. The 2-(chlormethylamino)-4,5-diphenylimdazole was reacted with piperazine and its derivatives, which yielded 2-(piperazinomethylamino)-4,5-diphenylimiazole and its respective derivatives. All the compounds were characterized on the basis of IR and 1HNMR spectral data were screened for antimicrobial activity.
Piper nigrum, Nyctanthes arbortristis, Safety and Efficacy, Antipyretic activity.
SP Wate, AN Ingale, PS Tarte. Synthesis and Antimicrobial Evaluation of Some 2- (Piperazinomethylamino) Imidazole Derivatives. Research J. Pharm. and Tech. 3(1): Jan. - Mar. 2010; Page 154-156.
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