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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   3

Issue No. :  1

Year :  2010

Pages :   154-156

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Synthesis and Antimicrobial Evaluation of Some 2- (Piperazinomethylamino) Imidazole Derivatives



Address:   SP Wate, AN Ingale and PS Tarte*
Sharad Pawar College of Pharmacy, Wandongari, Hingana Road, Nagpur-441110 (M. S.)
*Corresponding Author
DOI No: Not Available

ABSTRACT:
Benzoin was reacted with aminomethamine in ethanol to yield 2-amino-4,5-diphenylimidazole, which on further reaction with dichloromethane in presence of ethanolic potassium hydroxide yielded 2-(chloromethylamino)-4,5-diphenylimidazole. The 2-(chlormethylamino)-4,5-diphenylimdazole was reacted with piperazine and its derivatives, which yielded 2-(piperazinomethylamino)-4,5-diphenylimiazole and its respective derivatives. All the compounds were characterized on the basis of IR and 1HNMR spectral data were screened for antimicrobial activity.
KEYWORDS:
Piper nigrum, Nyctanthes arbortristis, Safety and Efficacy, Antipyretic activity.
Cite:
SP Wate, AN Ingale, PS Tarte. Synthesis and Antimicrobial Evaluation of Some 2- (Piperazinomethylamino) Imidazole Derivatives. Research J. Pharm. and Tech. 3(1): Jan. - Mar. 2010; Page 154-156.
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