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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   3

Issue No. :  1

Year :  2010

Pages :   141-145

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Stability Indicating RP-HPLC Method for Determination of Potassium Clavulanate in the presence of its Degradation Products



Address:   Sinha PK, Jeswani RM, Topgi KS and Damle MC
A.I.S.S.M.S College of Pharmacy, Near RTO, Kennedy Road, Pune, Maharashtra-411001, India
*Corresponding Author
DOI No: Not Available

ABSTRACT:
A stability indicating isocratic RP-LC method has been developed for the quantitative determination of Potassium Clavulanate in presence of its hydrolytic degraded products. Chromatographic separation was achieved on a C18 Nucleosil column with mobile phase consisting of 0.7% sodium dihydrogen phosphate and methanol in the ratio of 90: 10 v/v; retention time of the drug was 4.2±0.05 min, quantification was carried out at 230 nm with flow rate of 1 mL min-1. In the developed LC method the resolution between potassium Clavulanate and products of degradation was found to be greater than 2 with r2 value greater than 0.997.
KEYWORDS:
Stability indicating, Potassium Clavulanate, RP-HPLC.
Cite:
Sinha PK, Jeswani RM, Topgi KS, Damle MC. Stability Indicating RP-HPLC Method for Determination of Potassium Clavulanate in the presence of its Degradation Products. Research J. Pharm. and Tech. 3(1): Jan. - Mar. 2010; Page 141-145.
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