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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   3

Issue No. :  1

Year :  2010

Pages :   

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Formulation Strategy for Low Absorption Window Antihypertensive Agent



Address:   1Oriental College of Pharmacy, Thakral Nagar. Bhopal-462021, India 2PRES’S College of Pharmacy. Chincholi, Nashik-422101, India 3Lakshmi Narayan College of Pharmacy, Bhoapl-462021, India 4Sagar Institute of Pharmaceutical Sciences, Sagar-470 228, India
DOI No: Not Available

ABSTRACT:
An attempt was made to design and evaluate hydrodynamically balanced systems (HBS) of Diltiazem HCl hydrochloride using Locust bean gum and Methocel K4M as the polymers. All tablets contained an effervescent base consisting of sodium bicarbonate and citric acid. The tablets were prepared by direct compression method. All the designed nine batches of formulations were evaluated for hardness, friability, weight variation, drug content uniformity, swelling index, in vitro buoyancy, and drug release pattern. Estimation of diltiazem HCl in the prepared HBS was carried out by extracting drug with 0.1N HCl and analyzed at 236.4 nm spectrophotometricaly. All formulations had floating lag time below 3 minutes and constantly floated on dissolution medium for more than 24 hours. These studies indicate that the proper balance between Locust bean gum and Methocel K4M can produce a desired drug dissolution profile. The proposed formulation showed good physicochemical properties, good stability and controlled drug release pattern, thereby improving the bioavailability of the drug.
KEYWORDS:
Diltiazem HCl, Floating drug delivery systems, Absorption window
Cite:
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