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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   3

Issue No. :  1

Year :  2010

Pages :   

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Simultaneous Spectrophotometric Estimation and Validation of Metformin Hydrochloride and Glibenclamide in Bulk Drug and Pharmaceutical Dosage Form

Address:   1School of Pharmaceutical Sciences, Jaipur National University, Jagatpura, Jaipur-203025 Rajasthan, India. 2Department of Pharmacognosy, VNS College of Pharmacy, Bhopal (M.P.), India.
DOI No: Not Available

Two simple, accurate, economical and reproducible spectrophotometric methods for simultaneous estimation of two-component drug mixture of metformin hydrochloride and glibenclamide in bulk and combined tablet dosage form have been developed. The first method employs formation and solving of simultaneous equations using 237.0 and 229.2 nm as two analytical wavelengths. The second method is absorption ratio method, which uses 237.0 and 225.0 nm as two analytical wavelengths. Both methods were statistically validated according to International Conference on Harmonization and recovery studies confirmed the accuracy of the proposed method.
Simultaneous spectrophotometric analysis, Absorption ratio method, Metformin hydrochloride and Glybenclamide
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