Journal :   Research Journal of Pharmacy and Technology

Volume No. :   2

Issue No. :  4

Year :  2009

Pages :   749-752

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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A Validated RP-HPLC Method for Simultaneous Determination of Ramipril and Valsartan in Pharmaceutical Formulation



Address:   Shradhanjali M Singh, Kirti S Topagi, and Mrinalini C Damle*
Dep. of Pharmaceutical Chemistry, A.I.S.S.M.S. College of Pharmacy, Kennedy Road, Near R.T.O., Pune – 411001.
*Corresponding Author
DOI No:

ABSTRACT:
A simple, fast, accurate and precise method has been developed for the simultaneous determination of Ramipril and Valsartan from pharmaceutical formulation by reverse phase high performance liquid chromatography (RP-HPLC). The separation was carried out on Hypersil gold CN column using Acetonitrile and Water [pH adjusted to 3.0 with Orthophosphoric acid (0.08%)] in the ratio (70:30v/v). The retention times of Ramipril and Valsartan were 5.08 ? 0.02 and 3.68 ? 0.02 minutes respectively. The developed method was validated as per ICH Guidelines.
KEYWORDS:
Ramipril, Valsartan, RP-HPLC, Validation.
Cite:
Shradhanjali M Singh, Kirti S Topagi, Mrinalini C Damle. A Validated RP-HPLC Method for Simultaneous Determination of Ramipril and Valsartan in Pharmaceutical Formulation. Research J. Pharm. and Tech.2 (4): Oct.-Dec. 2009; Page 749-752.
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