Journal :   Research Journal of Pharmacy and Technology

Volume No. :   2

Issue No. :  4

Year :  2009

Pages :   732-737

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Development, In vitro Evaluation and Method selection for Preparation of Mucoadhesive Microcapsule for Oral delivery of Famotidine



Address:   Nayak Bhabani Shankar*1, Ghosh Sunil Kumar1, Nayak Udaya Kumar2, Patro K. Balakrishna3 and Patro K. Tripati Balaji4
1Department of Pharmaceutics, Faculty of Pharmacy, Jeypore College of Pharmacy, Rondapalli, Jeypore-764002, Koraput, Orissa
2College of Pharmaceutical Sciences, Mohuda, Berhampur – 760002, Ganjam, Orissa, India.
3Ajanta Pharma Ltd., Mumbai,
4Glenmark R&D unit, Navi Mumbai, India.
Corresponding Author
DOI No:

ABSTRACT:
The present study concerns with the preparation, evaluation and selection of a suitable method for the preparation of famotidine incorporated microcapsules using carbopol-934 as rate controlling polymer. Microcapsules were prepared from various methods, namely modified ionic gelation method (F1), emulsification-internal gelation method (F2), emulsification gelation method (F3), extrusion method (F4), emulsification-ionic gelation method (F5), emulsion-evaporation method (F6), ionotropic gelation method (F7), coacervation phase separation method (F8) and complex emulsion method (F9). The prepared microcapsules were evaluated for parameters such as percentage yield, particle size measurement, drug content estimation, drug entrapment efficiency, surface morphology study by scanning electron microscopy, sphericity determination, loose surface crystal study, percentage of moisture loss, in vitro drug release profile, in vitro drug release kinetic study, in-vitro mucoadhesion wash off test and accelerated stability studies. The famotidine microcapsules thus obtained were with good structure, satisfactory yield and high entrapment efficiency. Microcapsules exhibited slow release of famotidine over 9 hours with zero order release kinetic fashion. Among all the methods, ionotropic gelation method (F7) was most successful method in sustaining the release of famotidine in a controlled fashion from carbopol-934 microcapsules, which could be a novel trend for effective management of peptic ulcer. All data were verified statistically by employing one way ANOVA and found to be significant at 5 % level of significance.
KEYWORDS:
Swelling index, sphericity, ionotropic gelation, mucoadhesion.
Cite:
Nayak Bhabani Shankar, Ghosh Sunil Kumar, Nayak Udaya Kumar, Patro K. Balakrishna, Patro K. Tripati Balaji. Development, In vitro Evaluation and Method selection for Preparation of Mucoadhesive Microcapsule for Oral delivery of Famotidine. Research J. Pharm. and Tech.2 (4): Oct.-Dec. 2009,;Page 732-737.
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