Journal :   Research Journal of Pharmacy and Technology

Volume No. :   2

Issue No. :  4

Year :  2009

Pages :   730-731

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Estimation of Diltiazem Hydrochloride from Tablet Formulation Using Spectrophotometric Methods



Address:   Nagasuri Ravindra1, Singhvi Indrajeet2* and Pillai Sujit2
1Goenka College of Pharmacy, Lachhmangarh, Dist: Sikar. 332 313. Rajasthan, India.
2Pacific College of Pharmacy, Pratap Nagar Extension, Airport Road, Udaipur. 313 001. Rajasthan, India
*Corresponding Author
DOI No:

ABSTRACT:
Three simple and sensitive visible spectrophotometric methods have been developed for the quantitative estimation of diltiazem hydrochloride (DITZ) from tablet dosage form. The developed methods are based on formation chloroform extractable colored complex of drug with metanil yellow (MY, method A), tropaeolin 000 (TRP, method B) and alizarin red (AR, method C). The colored complex formed in method A, B, and C showed absorbance maxima at 405.5, 484.5 and 426.0 nm and linearity was observed in the concentration range of 3-24 µg/ml, 3-24 µg/ml and 10-80 µg/ml of DITZ respectively. The results obtained were statistically validated and were found to be reproducible.
KEYWORDS:
Diltiazem hydrochloride, Tablets, Spectrophotometric method.
Cite:
Nagasuri Ravindra, Singhvi Indrajeet, Pillai Sujit. Estimation of Diltiazem Hydrochloride from Tablet Formulation Using Spectrophotometric Methods. Research J. Pharm. and Tech.2 (4): Oct.-Dec. 2009; Page 730-731.
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