Journal :   Research Journal of Pharmacy and Technology

Volume No. :   2

Issue No. :  4

Year :  2009

Pages :   727-729

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Extractive Spectrophotometric Determination of Clopidogrel Bisulphite In Pharmaceutical Formulation



Address:   M Padmalatha1 and K Vanitha Prakash2*
1Vijaya College of Pharmacy, Munaganoor (V), Hyderabad- 501505,
2Sultan-Ul-Uloom College of Pharmacy, Mount Pleasant, Road No. 3, Banjara Hills, Hyderabad-500 034.
*Corresponding Author
DOI No:

ABSTRACT:
Three simple, economical, precise, reliable and reproducible visible spectrophotometric methods (A, B and C) have been developed for the estimation of Clopidogrel bisulphite in bulk as well as in Tablet formulation. The developed methods A, B and C are based on the formation of chloroform extractable complex of Clopidogrel bisulphite with Bromothymol Blue (Method A), Orange II (Method B), and Metanil yellow (Method C) which shows absorbance maxima at 440 nm, 490 nm and 410 nm respectively. The absorbance-concentration plot is linear over the range of 2.5-25 mcg/ml for Method A, and 2.5-20 mg/ml for Method B and 2.5-15 mcg/ml for Method C. The different experimental parameters affecting the development and stability were studied carefully and optimized. Results of analysis for all the methods were validated statistically and by recovery studies.
KEYWORDS:
Clopidogrel bisulphite, Bromothymol Blue, Orange II, Metanil yellow, Ultraviolet-Visible double beam spectrophotometer.
Cite:
M Padmalatha, K Vanitha Prakash. Extractive Spectrophotometric Determination of Clopidogrel Bisulphite In Pharmaceutical Formulation. Research J. Pharm. and Tech.2 (4): Oct.-Dec. 2009; Page 727-729.
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