Journal :   Research Journal of Pharmacy and Technology

Volume No. :   2

Issue No. :  4

Year :  2009

Pages :   705-709

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Natural Gums as Matrix and Coating Material for Colon Specific Drug Delivery



Address:   HK Kunjwani1*, AM Manikrao1 ,Rajesh KS1, Sable VP3 and NH Indurwade2
1 Parul Institute of Pharmacy, Limda Dist Vadodara (Gujrat) Pin-391760
2 Institute of Pharmacy, Wardha (M.S)
3 Baroda College of Pharmacy, Limda Dist Vadodara (Gujrat) Pin-391760
*Corresponding Author
DOI No:

ABSTRACT:
Colon specific matrix and coated tablet of 5-amino salicylic acid were formulated using biodegradable natural gums, Guar gum and Xanthan gum. The drug release behavior of fabricated tablets was investigated. Colon specific matrix tablet containing 200mg of 5- amino salicylic acid using different drug gum ratio of guar gum and Xanthan gum were prepared by wet granulation method. Formulations were optimized on the basis of acceptable tablet properties like hardness, friability, weight uniformity and in vitro drug release. In vitro dissolution studies were done in presence of fresh human feces for microbial degradation of gums. Results of in vitro dissolution studies indicated that matrix tablet containing 20 % guar gum was most successful showing better drug release profile. Xanthan gum when combined with guar gum further retards drug release.
KEYWORDS:
colon specific drug delivery, biodegradable gums, matrix tablet, and inflammatory bowel diseases.
Cite:
HK Kunjwani, AM Manikrao ,Rajesh KS, Sable VP, NH Indurwade. Natural Gums as Matrix and Coating Material for Colon Specific Drug Delivery. Research J. Pharm. and Tech.2 (4): Oct.-Dec. 2009; Page 705-709.
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