Journal :   Research Journal of Pharmacy and Technology

Volume No. :   2

Issue No. :  4

Year :  2009

Pages :   634-641

ISSN Print :  0974-3618

ISSN Online :  0974-360X


Registration

Allready Registrered
Click to Login

Nasal Absorption of Drugs – Barriers and Solutions



Address:   MH Dehghan1, Varsha M Gaikwad1* and Baby Dandge1
1Department of Pharmaceutics, Y. B. Chavan. College of Pharmacy, Dr. Rafiq Zakaria Campus, Rouza Bagh, Aurangabad-431001, Maharashtra. INDIA.
*Corresponding Author
DOI No:

ABSTRACT:
The large surface area of the nasal mucosa offers a rapid onset of therapeutic effect, potential for direct to central nervous system delivery; no first pass metabolism and non invasiveness all of these maximize patient convenience, comfort and compliance. Interest in intranasal administration as a non invasive route of drug delivery continues to grow rapidly. Although there is an increasing need to identify novel approaches by which to improve the efficacy of drug transport from nasal cavity. For this, it is necessary to know about the mechanism of the nasal absorption, factors affecting absorption and what are the strategies that will help to improve the nasal absorption of the drug.
KEYWORDS:
Nasal absorption,p-glycoprotein,olfactory mucosa.
Cite:
MH Dehghan, Varsha M Gaikwad, Baby Dandge. Nasal Absorption of Drugs – Barriers and Solutions. Research J. Pharm. and Tech.2 (4): Oct.-Dec. 2009; Page 634-641.
[View HTML]      [View PDF]



Visitor's No. :   366544