2nd International Conference on Fostering Interdisciplinary Research In Health Sciences (ICFIRHS) 2019 (01-May-2019)        |

Journal :   Research Journal of Pharmacy and Technology

Volume No. :   2

Issue No. :  4

Year :  2009

Pages :   617-620

ISSN Print :  0974-3618

ISSN Online :  0974-360X


Allready Registrered
Click to Login

Future of Cancer Therapy-COX-2 Inhibitors: A Review

Address:   Bhasker. S1*, Sandeep. G2 and Ranganath YS3
1Department of Pharmacology, University College of Pharmaceutical Sciences, Kakatiya University, Warangal-506002, Andhra Pradesh.
2Department of Pharmaceutics, J.K.K.M.M.R.F. College of Pharmacy, Komarapalayam, Pin
638183, Namakkal, Tamilnadu
3Department of Pharma. Chemistry, G. Pulla Reddy College of Pharmacy, Mehdipatnam, Hyderabad-500082
*Corresponding Author

Cycloxygenases (COX) are the principle enzymes involved in the metabolism of arachidonic acid generating prostaglandins which are the genuine mediators of inflammation and pain. COX are classified into Type-1 and Type-2 which are constitutive and inducible respectively. Recent research has brought into light the possible role of these PGs in the COX-2 cascade of tumor proliferation, angiogenesis and metastasis with significant overexpression. Thus COX-2 can serve as a useful biomarker in the early diagnosis and can be selectively targeted in the tumour cells with greater proven safety. The review deals with the potential role of COX-2 inhibitors in canceling the PG mediated Signaling, the role of COX-2 in different types of cancers. (Lung, Head and Neck, Bladder, Cervical Cancer and Other Oncology applications), the beneficial outcomes of combination therapy of COX-2 inhibitors along with either chemotherapy or radiotherapy. In conclusion a note on future research options for treating neuroblastomas with COX-2 inhibitors was elucidated.
Cycloxygenases, Prostaglandins, cancer, angiogenesis and over expression.
Bhasker. S, Sandeep. G, Ranganath YS. Future of Cancer Therapy-COX-2 Inhibitors: A Review. Research J. Pharm. and Tech.2 (4): Oct.-Dec. 2009; Page617-620.
[View HTML]      [View PDF]

Visitor's No. :   641859