List of Refereed Journals published by UGC, New Delhi on 28-03-2017-- AJRC (Sr. No.-1025); AJM (Sr. No.-2497); RJET (Sr. No.-7220); RJPP (Sr. No.- 7232): RJPPD (Sr. No.- 7234); RJPT (Sr. No.-7235) (19-Apr-2017)        | List of Refereed Journals published by UGC, New Delhi on 11-01-2017-- Research Journal of Pharmacy and Technology (Sr. No.-275); Asian Journal of Management (Sr. No.-3986); Asian Journal of Research in Chemistry (Sr. No.-4008); Research Journal of Engineering and Technology (Sr. No.-31787); Research (22-Jan-2017)        |

Journal :   Research Journal of Pharmacy and Technology

Volume No. :   2

Issue No. :  4

Year :  2009

Pages :   

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Design and Dissolution Study of Colon Specific Drug Delivery System of Tinidazole



Address:   Department of Pharmaceutical Sciences R.T.M., Nagpur University, Nagpur-440033, India.
DOI No: Not Available

ABSTRACT:
A novel, colon-targeted delivery system, which uses lactulose, was investigated in this study. Lactulose is not absorbed in the upper GI tract, but degraded to organic acids by enterobacteria in the lower gastrointestinal tract, especially the colon. A CODESTM consists of three components: a core containing lactulose and the drug, an inner acid-soluble material layer, and an outer layer of an enterosoluble material. A CODESTM containing Tinidazole shown protections against pH 1.2 and pH 6.8 upto six hour study. Formulation shown release at pH 5.0. The results of this study show that lactulose can act as a trigger for drug release in the colon, utilizing the action of enterobacteria.
KEYWORDS:
Anti-inflammatory activity, Fabaceae, Flemingia strobilifera, Kusrunt, Wild hops.
Cite:
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